![]() ![]() DIM blocks mTOR and subsequently inhibits the growth.DIM is a phytoestrogen and not an anti-Estrogen.DIM is a testosterone blocker and not an estrogen blocker.However, it is important for athletes using DIM as part of a muscle-building campaign to know that mTOR is the main anabolic pathway necessary for muscle hypertrophy and DIM will also block mTOR stimulation of cell growth. mTOR is necessary for cell growth and for this mechanism DIM is currently being researched as a potential tool for reducing the growth of cancer and tumors this research is still a long way from being able to make any solid anti-cancer claims for DIM. Higher doses of DIM act systemically to block anabolic androgens and mTOR pathways. When testosterone is adequate or high and estrogen is relatively low as seen in males, menopause, andropause, PCOS, “metabolic damage” post comp and in female athletes with low body fat and low estrogen levels DIM will bind and activate estrogen receptors to increase estrogen activity while blocking the androgen receptors to decrease testosterone activity. Phytoestrogens work to maintain a certain amount of hormonal activity. In estrogen deficit, DIM increases estrogen activity. The lack of effect may possibly be due to the need for the other glucosinolates compounds and the cofactors methylated folate and vitamin B12, which are necessary for this pathway. The research on DIM for this purpose is not adequate, with small groups and short durations, and is far from convincing. Very low doses of DIM (less than 100mg daily) in combination with other sulforaphane's and necessary cofactors folate and B12 as found in nature can help alter estrogen detoxification pathways in the gut and liver and improve the 2:16 alpha hydroxyl estrone ratios to reduce excessive estrogen activity. DIM was found to be more stable and more suitable for use in supplements. Indole-3-carbinol was studied extensively and found to be effective and beneficial for cancers but was shown to be very unstable. Broccoli also contains glucobrassicin, the glucosinolate precursor of indole-3-carbinol (I3C), and subsequently Diindolylmethane (DIM). Glucoraphanin is a stable plant glucosinolate that is converted to the active isothiocyanate, sulforaphane by an enzyme known as myrosinase. These foods contain a multitude of beneficial phytonutrients, activated vitamins, and cofactors in particular glucosinolates. The discovery of DIM stems from research on the anticancer potential of a diet high in cruciferous brassica vegetables such as broccoli, broccoli sprouts, radishes, pak Choy, kale, brussels sprouts and cabbages. Dim - Diindolylmethane is an anti-estrogen This is one of the ways DIM can help in cases of prostate cancer the other way is by inhibiting mTOR pathways that lead to cell growth and division but we will discuss mTOR in greater detail later when we discuss muscle hypertrophy. testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. Higher doses (greater than 100mg) of isolated pure DIM can saturate tissues and block androgen (e.g. If you wish to comment on product selection, pricing, ordering, delivery or other issues, please contact our customer service.Share on Facebook Tweet on Twitter Pin on Pinterest Email this page DIM - Diindolylmethane is an androgen antagonist!ĭIM blocks the effects of testosterone. ![]() We reserve the right to remove non-compliant reviews language. Personal information such as email addresses, phone numbers or physical addressesĪll reviews are subject to our Terms of Use.Advertising, spam, references to other websites or retailers.Critical or inappropriate comments about other reviews and shoppers.Language referencing a state of disease (including but not limited to references to pain, aches, inflammation, medicine replacement, cancer, cold/flu, arthritis, depression, insomnia, etc.). ![]() To meet our publishing standards, please refrain from including the following in your review: Be sure to explain why you like or dislike the product and focus on the product's features. We value your input and look forward to hearing about your personal product experiences. Reviews containing references to a state of disease (e.g., pain, aches, inflammation, medicine replacement, cancer, cold/flu, arthritis, depression, insomnia, etc.) cannot be published. ![]()
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